Event-related potentials: search for positive and negative child-related schemata in individuals at low and high risk for child physical abuse     

Milner JS  Rabenhorst MM  McCanne TR  Crouch JL  Skowronski JJ  Fleming MT  Hiraoka R  Risser HJ 《Child abuse & neglect》2011,35(4):249-266

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Unpacking the effects of adverse regulatory events: Evidence from pharmaceutical relabeling     

Matthew J. Higgins  Xin Yan  Chirantan Chatterjee 《Research Policy》2021,50(1):104126

We provide causal evidence that regulation induced product shocks significantly impact aggregate demand and firm performance in pharmaceutical markets. Event study results suggest an average loss between $569 million and $882 million. Affected products lose, on average, $186 million over their remaining effective patent life. This leaves a loss of between $383 million and $696 million attributable to declines in future innovation. Our findings complement research that shows drugs receiving expedited review are more likely to suffer from regulation induced product shocks. Thus, it appears we may be trading off quicker access to drugs today for less innovation tomorrow. Results remain robust to variation across types of relabeling, market sizes, and levels of competition.  相似文献   

Out on the Web: The Relationship between Campus Climate and GLBT-related Web-based Resources in Academic Libraries     

Matthew P. Ciszek 《The Journal of Academic Librarianship》2011,37(5):430-436

This article explores the relationship between the perceived campus environment for gay, lesbian, bisexual, and transgender (GLBT) students at colleges and universities and how academic libraries have deployed GLBT-related resources on the Web. Recommendations are made for increasing GLBT-related materials and information in academic libraries.  相似文献   

Real time search on the web: Queries,topics, and economic value     

Bernard J. Jansen  Zhe Liu  Courtney Weaver  Gerry Campbell  Matthew Gregg 《Information processing & management》2011

Real time search is an increasingly important area of information seeking on the Web. In this research, we analyze 1,005,296 user interactions with a real time search engine over a 190 day period. Using query log analysis, we investigate searching behavior, categorize search topics, and measure the economic value of this real time search stream. We examine aggregate usage of the search engine, including number of users, queries, and terms. We then classify queries into subject categories using the Google Directory topical hierarchy. We next estimate the economic value of the real time search traffic using the Google AdWords keyword advertising platform. Results shows that 30% of the queries were unique (used only once in the entire dataset), which is low compared to traditional Web searching. Also, 60% of the search traffic comes from the search engine’s application program interface, indicating that real time search is heavily leveraged by other applications. There are many repeated queries over time via these application program interfaces, perhaps indicating both long term interest in a topic and the polling nature of real time queries. Concerning search topics, the most used terms dealt with technology, entertainment, and politics, reflecting both the temporal nature of the queries and, perhaps, an early adopter user-based. However, 36% of the queries indicate some geographical affinity, pointing to a location-based aspect to real time search. In terms of economic value, we calculate this real time search stream to be worth approximately US $33,000,000 (US $33 M) on the online advertising market at the time of the study. We discuss the implications for search engines and content providers as real time content increasingly enters the main stream as an information source.  相似文献   

Conveying quality and value in emerging industries: Star scientists and the role of signals in biotechnology     

Matthew J. Higgins  Paula E. StephanJerry G. Thursby 《Research Policy》2011,40(4):605-617

This paper addresses the role that scientific status plays in initial public offerings of technology focused firms. The paper builds on the literature of the sociology of science as well as the work of Spence (1974) and Podolny (1993) and argues that the presence of a Nobel laureate affiliated with a firm making an IPO provides a signal of firm quality to potential investors. Moreover, and building on the work of Podolny and Scott Morton (1999) and Stuart et al. (1999) we hypothesize that the importance of status diminishes as other measures of firm quality become available. We test our hypothesis for two periods of initial public offerings in biotechnology. We document that there is a clear difference in “maturity” of the firms across the two windows on a number of metrics. Consistent with our hypothesis that Nobel laureates play an important role as a non-financial signal of firm quality, we find that first-window firms with a Nobel laureate affiliate realize greater IPO proceeds in the amount of $24 million. In the second window the amount of money raised is not significantly different between Nobel and non-Nobel firms. This finding is consistent with the signaling literature that argues that the importance of a signal is inversely related to the availability of cogent information on firm quality. Consistent with this view, we also find a change between the two windows in the importance of other non-financial metrics used to convey value. Our research is one of the first to examine the dynamic nature of signals. Because we are unable to distinguish the extent to which the reduction in uncertainty at the firm level is correlated with the reduction of uncertainty at the industry level, the question remains as to the extent to which the diminished importance of signals in our second period is due to a change in market uncertainty versus a change in firm uncertainty.  相似文献   

Use of dual-task methodology for skill assessment and development: examples from rugby league   总被引：2，自引：1，他引：1  

Gabbett T  Wake M  Abernethy B 《Journal of sports sciences》2011,29(1):7-18

We assessed the attentional demands of drawing and passing in rugby league players and investigated the effects of single-task and dual-task training on the acquisition, retention, and transfer of skill in these athletes. In Study 1, high-skilled and lesser-skilled rugby league players performed a standardized 2-on-1 drill under single-task (primary skill in isolation) and dual-task (primary skill while performing a secondary verbal tone recognition task) conditions. No differences were detected in primary task performance between groups, although the performance of the high-skilled players was more resistant to skill decrement under dual-task conditions. In Study 2, high-performance rugby league players were randomly allocated to either a single-task or dual-task training group. Each group underwent 8 weeks of training between the pre- and post-test sessions. While the mean improvement for draw and pass proficiency under dual-task conditions in the dual-task training group was greater than in the single-task training group (10.0% vs. 2.3%), the differences, while providing a moderate effect size (d = 0.57), were not statistically significant. These results suggest that the attentional demands of drawing and passing are reduced in high-skilled rugby league players compared with their lesser-skilled counterparts. In addition, compared with single-task training, dual-task training appears to improve the ability to perform dual-task draw and pass tasks (possibly through an improvement in time-sharing skills). Further studies are required to verify the efficacy of dual-task training as a training stimulus.  相似文献   

Masculinity, moral atmosphere, and moral functioning of high school football players     

Steinfeldt JA  Rutkowski LA  Vaughan EL  Steinfeldt MC 《运动与训练心理学杂志》2011,33(2):215-234

In order to identify factors associated with on-field moral functioning among student athletes within the unique context of football, we examined masculine gender role conflict, moral atmosphere, and athletic identity. Using structural equation modeling to assess survey data from 204 high school football players, results demonstrated that moral atmosphere (i.e., the influence of coaches and teammates) was significantly associated with participants' process of on-field moral functioning across the levels of judgment, intention, and behavior. Neither masculine gender role conflict nor athletic identity significantly predicted moral functioning, but the results indicated that participants' identification with the athlete role significantly predicted conflict with socialized gender roles. Results suggest that in the aggressive and violent sport of football, coaches can have a direct influence on players' moral functioning process. Coaches can also have an indirect effect by influencing all the players so that a culture of ethical play can be cultivated among teammates and spread from the top down.  相似文献   

Separation and enrichment of sodium-motile bacteria using cost-effective microfluidics     

Jyoti P. Gurung  Moein Navvab Kashani  Sanaz Agarwal  Gonzalo Peralta  Murat Gel  Matthew A. B. Baker 《Biomicrofluidics》2021,15(3)

Many motile bacteria are propelled by the rotation of flagellar filaments. This rotation is driven by a membrane protein known as the stator-complex, which drives the rotor of the bacterial flagellar motor. Torque generation is powered in most cases by proton transit through membrane protein complexes known as stators, with the next most common ionic power source being sodium. Sodium-powered stators can be studied through the use of synthetic chimeric stators that combine parts of sodium- and proton-powered stator proteins. The most well studied example is the use of the sodium-powered PomA-PotB chimeric stator unit in the naturally proton-powered Escherichia coli. Here we designed a fluidics system at low cost for rapid prototyping to separate motile and non-motile populations of bacteria while varying the ionic composition of the media and thus the sodium-motive force available to drive this chimeric flagellar motor. We measured separation efficiencies at varying ionic concentrations and confirmed using fluorescence that our device delivered eightfold enrichment of the motile proportion of a mixed population. Furthermore, our results showed that we could select bacteria from reservoirs where sodium was not initially present. Overall, this technique can be used to implement the selection of highly motile fractions from mixed liquid cultures, with applications in directed evolution to investigate the adaptation of motility in bacterial ecosystems.  相似文献   

Anatomy integration blueprint: A fourth‐year musculoskeletal anatomy elective model          下载免费PDF全文

Michelle D. Lazarus  Gordon L. Kauffman Jr.  Milind J. Kothari  Timothy J. Mosher  Matthew L. Silvis  John R. Wawrzyniak  Daniel T. Anderson  Kevin P. Black 《Anatomical sciences education》2014,7(5):379-388

Current undergraduate medical school curricular trends focus on both vertical integration of clinical knowledge into the traditionally basic science‐dedicated curricula and increasing basic science education in the clinical years. This latter type of integration is more difficult and less reported on than the former. Here, we present an outline of a course wherein the primary learning and teaching objective is to integrate basic science anatomy knowledge with clinical education. The course was developed through collaboration by a multi‐specialist course development team (composed of both basic scientists and physicians) and was founded in current adult learning theories. The course was designed to be widely applicable to multiple future specialties, using current published reports regarding the topics and clinical care areas relying heavily on anatomical knowledge regardless of specialist focus. To this end, the course focuses on the role of anatomy in the diagnosis and treatment of frequently encountered musculoskeletal conditions. Our iterative implementation and action research approach to this course development has yielded a curricular template for anatomy integration into clinical years. Key components for successful implementation of these types of courses, including content topic sequence, the faculty development team, learning approaches, and hidden curricula, were developed. We also report preliminary feedback from course stakeholders and lessons learned through the process. The purpose of this report is to enhance the current literature regarding basic science integration in the clinical years of medical school. Anat Sci Educ 7: 379–388. © 2014 American Association of Anatomists.  相似文献   

THE ROLE OF PRUDENCE IN EDUCATION     

Matthew Morgan 《Educational theory》2003,53(2):173-183

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